LED medical applications further scientists develop ultra-fine LED probes


Before finding a cure for Alzheimer's disease, scientists need to develop a solution that will give them a better understanding of how the brain interacts. Researchers at the University of Michigan have recently taken a big step toward this goal and have developed the smallest brain implantable LED probes available today. In the field of optogenetics, implanted fibers are used to stimulate brain cells (to expose them to light pulses), while a second device records the next reaction.

Scientists at the University of Michigan say that such a setup doesn't really record how neurons can communicate with each other, but their new probes do.

Each probe has a width of less than 0.1 mm (no more than 1 neuron cell body) and contains 12 LEDs and 32 electrodes, any of which can be used to activate a neuron.

When doing so, the electrodes are able to detect any response from other neurons in the surrounding network. In a related study on how animals form memories, New York University has already tested this technique on experimental mice.

Fan Wu, a postdoctoral fellow at the University of Michigan, said: "Now we can know how a group of cells in the vicinity and in the distance react to a single activated cell, which will help us better understand the inter-cell communication."

A paper on the probe has been published in the recently published journal Neuron. Scientists at the University of Illinois and the University of Washington have previously developed LED single-pins for activating neurons, but did not include electrodes for detecting response.

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